Impact of Chemotherapy on Protein Levels in Cancer Patients Undergoing Treatment
Keywords:
Chemotherapy, Spectrophotometry, TumourAbstract
Cancer staging is a critical component of cancer management and directly influences the patient's treatment approach. Numerous protein tumor indicators assist in the diagnosis and prognosis of cancer patients. The objective of this study is to assess the total protein levels in serum samples from chosen cancer patients and to identify any correlations with various stages of the disease. Materials and Methods: Total proteins were quantified using the IR-VS spectroscopy approach and compared among various patients. Outcome: The spectrophotometric examination of the obtained serum samples indicated that chemotherapy-induced total protein loss correlates with the dysregulation of serum proteins and electrolytes. Total protein serves as a crucial indicator for assessing tumor stage in cancer patients; hence, it functions as a prognostic marker as well. It is a straightforward, non-invasive, and economical analytical approach
References
M. Ziętarska, J. Krawczyk-Lipiec, L. Kraj, R. Zaucha, and S. Małgorzewicz, “Chemotherapy-related toxicity, nutritional status and quality of life in precachectic oncologic patients with, or without, high protein nutritional support. A prospective, randomized study,” Nutrients, vol. 9, no. 10, p. 1108, 2017.
V. Schirrmacher, “From chemotherapy to biological therapy: A review of novel concepts to reduce the side effects of systemic cancer treatment,” Int. J. Oncol., vol. 54, no. 2, pp. 407–419, 2019.
O. Arrieta et al., “Association of nutritional status and serum albumin levels with development of toxicity in patients with advanced non-small cell lung cancer treated with paclitaxel-cisplatin chemotherapy: a prospective study,” BMC Cancer, vol. 10, no. 1, p. 50, 2010.
X. Sui et al., “Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment,” Cell Death Dis., vol. 4, no. 10, pp. e838–e838, 2013.
R. Oun, Y. E. Moussa, and N. J. Wheate, “The side effects of platinum-based chemotherapy drugs: a review for chemists,” Dalton transactions, vol. 47, no. 19, pp. 6645–6653, 2018.
P. Bouwman and J. Jonkers, “The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance,” Nat. Rev. Cancer, vol. 12, no. 9, pp. 587–598, 2012.
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